October 2025 Newsletter

Thank you for your continued support of the DETECT-2 study

We have many achievements to celebrate!

This newsletter contains the following updates:

1. Welcome to newly-opened sites

2. Study Recruitment Update

3. Healthcare Staff Questionnaire

4. Trial operational reminders

5. Study activities and case record forms to complete

6. REDCap Data Entry Reminders

We now have 25 sites open to recruitment!

Congratulations to the following sites that have opened since our last newsletter:

Somerset NHS Foundation Trust
NHS Lothian- Edinburgh
Leeds Teaching Hospital NHS Trust
University Hospital Southampton NHS Foundation Trust

We are working with 5 other sites and look forward to opening them in the coming months.

We are still looking for other recruiting sites to join the DETECT-2 study. Please share this information and encourage interested sites to contact us!

Special thanks to Manchester University NHS Foundation Trust for recruiting so well over the last few months! As a thank you, they will be receiving a sweet treat from the central study team!

Study Recruitment Update

We are pleased to share that we now have 298 participants recruited to the study!

A heartfelt thank you to all our sites for your support in helping us reach this milestone.

Healthcare Staff Questionnaire

We are gathering feedback from health professionals involved in the direct-to-patient (DTP) genetic testing pathway used in the DETECT-2 study. Please look out for a brief questionnaire sent to the eligible site team members and kindly complete it

Ensuring eligibility for the study before recruitment

Cancer patients often have long treatment pathways involving multiple teams. Before recruiting, please confirm they haven’t already had genetic testing. In addition to checking with the patient and reviewing records, contact the treating team if the testing status is unclear.

Updating the Central Team with Site Team Details

As NHS Trusts transition from local email addresses to nhs.net, please ensure the central study team is kept up to date with the current email addresses of all site team members. Also,please notify the central team of any updates to the site team involved in the study.

REDCap Data Entry Reminders

To support accurate data collection and ensure smooth study operations, please take note of the following key reminders:

Key Dates for Study Processes

‘Date of consent to genetic testing’, ‘Date genetic testing results given to patient’ are essential for the central study team to coordinate follow-up questionnaires. Without the consent date, the post-decision questionnaire cannot be sent, and if the result date is entered too late, it may be missed. Hence we request timely updating of these dates.

Baseline Questionnaires

Baseline questionnaires is a site team activity and should be issued in only one format either electronic or paper for each participant. If a questionnaire needs to be resent, please use the same format as the original to avoid duplication.

Use the ‘Resolve Issues’ Tab

The ‘Resolve Issues’ tab on REDCap is a helpful tool to view and address outstanding data queries. Please check it regularly to stay on top of any unresolved issues.

We sincerely thank all of our team members, collaborators, supporters, funders, and (most importantly) patients involved in the DETECT-2 trial.